Catalog/Longevity

Longevity

MOTS-c

Mitochondrial ORF of the 12S rRNA type-c

A 16-residue peptide encoded in the mitochondrial genome, researched for AMPK activation and metabolic stress responses.

Sequence

  • Hydrophobic
  • Polar
  • Charged
MRWQEMGYIFYPRKLR
CAS
1627580-64-6
Formula
C101H152N28O22S2
Mass (g/mol)
2174.64
Half-life
Short in plasma
Form
Lyophilized acetate
Purity
≥98% HPLC

Mechanism

Translocates to the nucleus under metabolic stress. Linked to folate-methionine cycling and AMPK in published mouse work.

Research notes

Methionine and tryptophan make it oxidation-sensitive.

Lyophilized: −20 °C.

Typical reconstitution

Catalog convenience numbers — not a protocol. Vial 10 mg in 2 mL; default draw 500 mcg.

Adjacent